This is the mainstay of modern railway operation: a train that can run in either direction with no discernible "locomotive". Unsurprisingly, we have several of these, between two and 8 units long. They can visit any passenger station (although the Eurostar is blocked from Clanfield because it is too long).
These trains are very simple to run in Traincontroller. You simply tell them to go from A to B and they do, because they don't need to worry about direction. All of our unit either have resistor wheelsets at the "undriven" end or a lighting decoder, so they present an electrical load. That means that either end of the train is detected by the occupancy detectors, and either end will be automatically stopped on reaching a platform.